Publications

42. Kim, H; Kim, U; Ji, C. H.; Shin, H. Y.; Shim, S. H.; Kang, H. S. "Rapacrycins, new polyene natural products discovered through heterologous expression of a reducing type II PKS biosynthetic gene cluster with a new hybrid genotype." - Manuscript in Preparation

41. Ji, C. H.; Kim, C. I.; Yun, B.; Kim, J. Y.; Kang, S.W.; Oh, D. C.; Kang, H. S. "Deazapurine amide bond synthetases: a new family of amide bond-forming enzymes driving the diversity of peptidyl deazapurine natural products." J. Am. Chem. Soc. 2025, 147(45), 41668-41677 (IF15.7)

40. Lee, H.T.; Mohite, O. S.; Kwon, M. S.; Kang, H.-S.; Weber, T.; Lee, S. Y.; Kim, H. U. "Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism" Metabolic Engineering 2025, 92(1), 241-251 (IF 6.8)

39. Park, S.; Je, H. W.; Cha, Y.; Gu, B.; Cho, Y.; Kim, J. I.; Seo, J. W.; Kim, S. B.; Son, J.; Hur, M.; Sung, C.; Oh, M. K.; Kang, H. S. "Exploring the biosynthetic potential of Korean Actinobacteria for antibacterial metabolite discovery." Journal of Microbiology 2025, 63(9), e2504002 (IF 3.3)

38. Kim, HY; Ahn, J.; Kim, J.; Kang, H.S. "Metagenomic insights and biosynthetic potential of Candidatus Entotheonella symbiont associated with Halichondria marine sponges" Microbiology Spectrum 2025, 13(1), e02355-24. (IF 3.7)

37. Ji, C. H.; Park, S. H.; Lee, K. W.; Je, H. W.; Kang, H. S. "Lipidation engineering in daptomycin biosynthesis" J. Am. Chem. Soc. 2024, 146(44), 30434-30442 (IF 14.5)

36. Ji, C. H.; Je, H. W.; Kim, H.; Kang, H. S. "Promoter engineering of natural product biosynthetic gene clusters in Actinomycetes: Concepts and Applications." Nat. Prod. Rep. 2024, 41, 672-699. (IF 11.9)

35. Lee, S.; Park, I. G.; Choi, J. W.; Song, J. Y.; Lee, J. W.; Hur, J.-S.; Kim, Y.; Nam, S.-J.; Kang, H. S.; Deyrup, S. T.; Noh, M.; Shim, S. H. "Daldipyrenones A-C: Caged [6,6,6,6,6] polyketides derived from an endolichenic fungus Daldinia pyrenaica 047188" Org. Lett. 2023, 25(36), 6725-6729. (IF 5.2)

34. Kim, H.; Kim, J. Y.; Ji, C. H.; Lee, D.; Shim, S. H.; Joo, H. S.; Kang, H. S. "Acidonemycines A-C, new glycosylated anthracyclines with anti-virulence activity produced by the acidic culture of Streptomyces indonesiensis." J. Nat. Prod. 2023, 86, 8, 2039-2045 (IF 5.1)

33. Choi, J. W.; Lee, Y.; Kim, J.; Kwon, H.; Deyrup, S. T.; Lee, J. W.; Lee, D.; Kang, H. S.; Joo, H.; Shim, S. H. "Discovery of bioactive metabolites by acidic stress to a geldanamycin producer, Streptomyces samsunensis." J. Nat. Prod. 2023, 86, 947-957. (IF 5.1)

32. Je, H. W.; Ji, C. H.; Kim, H; Kang, H. S. "CaExTun: Mitigating Cas9-related toxicity in Streptomyces through species-specific expression tuning with randomized constitutive promoters." ACS Synth. Biol. 2023, 12, 61-70. (IF 5.249)

31. Ku, H; Lee, Y; Lee, S; Lee, J. W.; Kang, H. S.; Joo, H.-S.; Shim, S. H. "New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity" J. Antibiot. 2023, 76, 57-64. (IF 3.424)

30. Ji, C. H.; Kim, H. Y.; Je, H. W.; Lee, D. H.; Kang, H. S. "Top-down synthetic biology approach for titer improvement of clinically important antibiotic daptomycin in Streptomyces roseosporus NRRL11379." Metabolic Engineering 2022, 69(1), 40-49. (IF 9.783)

29. Chung, Y. H.; Kim, H.; Ji, C. H.; Je, H. W.; Lee, D.; Shim, S. H.; Joo, H. S.; Kang, H. S. "Comparative genomics reveals a remarkable biosynthetic potential of the Streptomyces phylogenetic lineage associated with rugose ornamented spores." mSystems 2021, 6(4), e00489-21 (IF 6.496)

28. Kang, H. S.; Kim, E. S. "Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts." Curr. Opin. Biotechnol. 2021, 69, 118-127. (IF 8.288)

27. Kim, HY.; Ji, C. H.; Je, H. W.; Kim, J. P.; Kang, H. S. "mpCRISTAR: Multiple plasmid approach for CRISPR/Cas9 and TAR-mediated multiplexed refactoring of natural product biosynthetic gene clusters." ACS Synth. Biol. 2020, 9(1), 175-180. (IF 5.571)

26. Ji, C. H.; Kim, HY.; Kang, H. S. "Synthetic inducible regulatory systems optimized for the modulation of secondary metabolite production in Streptomyces." ACS Synth. Biol. 2019, 8(3), 577 - 586. (IF 5.316)

25. Ji, C. H.; Kim, J. P.; Kang, H. S. "Library of synthetic Streptomyces regulatory sequences for use in promoter engineering of natural product biosynthetic gene clusters." ACS Synth. Biol. 2018, 7(8), 1946-1955. (IF 5.316)

24. May D. S.; Kang, H. S.; Santarsiero B. D.; Krunic A.; Shen Q.; Burdette J. E.; Swanson S. M.; Orjala J. "Ribocyclophanes A-E, glycosylated cyclophanes with antiproliferative activity from two cultured terrestrial Cyanobacteria." J. Nat. Prod. 2018, 81, 572-8. (IF 3.885)

*Co-first author

23. Kang, H. S.; Ji, S. A.; Park, S. H.; Kim, J. P. "Lepistatins A-C, chlorinated sesquiterpenes from the cultured Basidiomycete Lepista sordida. " Phytochemistry 2017, 143, 111-4. (IF 3.205)

22. Kang, H. S. "Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products." J. Ind. Microbiol. Biotechnol. 2017, 44, 285-93. (IF 2.81)

- Featured in the cover

21. Kang, H. S.; Kim, J. P. "Ostalactones A - C, β- and ε-lactones with lipase inhibitory activity from the cultured Basidiomycete Stereum ostrea." J. Nat. Prod. 2016, 79, 3148-51. (IF 3.885)

20. Kang, H. S.; Charlop-Powers, Z.; Brady, S. F. "Multiplex CRISPR/Cas9- and TAR-mediated promoter engineering of natural products biosynthetic gene clusters." ACS Synth. Biol. 2016, 16, 1002-10. (IF 6.076)

19. Cohen, L. J.; Kang, H. S.; Chu, J.; Huang, Y. H.; Gordon, E. A.; Reddy, B. V.; Ternei, M. A.; Craig, J. W.; Brady, S. F. "Functional metagenomic discovery of bacterial effectors in the human microbiome led to the isolation of GPCR G2A/132 agonist commendamide." Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 4825-34. (IF 9.661)

18. Montiel, D.; Kang, H. S.; Chang, F. Y.; Charlop-Powers Z.; Brady, S. F. " Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. " Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 8953-8. (IF 9.661)

*Co-first author

17. Luos, S.; Kang, H. S.; Krunic, A.; Chen, W. L.; Yang, J.; Woodard, J. L.; Fuchs, J. R.; Cho, S. H.; Franzblau, S. G.; Swanson, S. M.; Orjala, J. "Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscilatoria sp. UIC 10045" Bioorg. Med. Chem. 2015, 23, 3153-62. (IF 2.93)

16. Kang, H. S.; Brady, S. F. "Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study." J. Am. Chem. Soc. 2014, 136, 18111-18119. (IF 13.858)

15. Luo, S.; Krunic, A.; Kang, H. S.; Chen, W.-L.; Woodard, J.; Fuchs, J.; Swanson, S.; Orjala, J. "Trichormamides A and B with antiproliferative activity from the cultured freshwater Cyanobacterium Trichormus sp. " J. Nat. Prod. 2014, 77, 1871-1880. (IF 3.281)

14. Biggins, J. B.; Kang, H. S.; Ternei, M. A.; DeShazer, D.; Brady, S. F. "Secondary metabolism of Burkholderia pseudomallei is essential for pathogenicity." J. Am. Chem. Soc. 2014, 136, 9484-9490. (IF 13.858, JCR top 10%)

13. Kang, H. S.; Brady, S. F. "Arixanthomycins A-C: phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. " ACS Chem. Biol. 2014, 9, 1267-1272. (IF 4.995, JCR top 30%)

12. Luo, S.; Kang, H. S.; Krunic, A.; Chlipala, G. E.; Cai, G.; Chen, W. L.; Franzblau, S. G.; Swanson, S. M.; Orjala, J. "Carbamidocyclophanes F and G with anti-Mycobacterium tuberculosis activity from the cultured freshwater cyanobacterium Nostoc sp." Tetrahedron Lett. 2014, 55, 686-689. (IF 2.193)

11. Kang, H. S.; Brady, S. F. "Arimetamycin A: improving clinically relevant families of natural products through sequence guided screening of soil metagenomes." Angew. Chem. Int. Ed. 2013, 52, 11063-11067. (IF 11.994)

- Selected as the cover paper

10. Kallifidas, D.; Kang, H. S.; Brady, S. F. "Tetarimycin A, an MRSA active antibiotic identified through induced expression of environmental DNA gene clusters." J. Am. Chem. Soc. 2012, 134, 19552-19555. (IF 13.858)

- Highlighted by C&E News and Nature medicine

9. Kang, H. S.; Sturdy, M.; Krunic, A.; Kim, H. J.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides E – L, antiproliferative cyclic lipodecapeptides from the cultured cyanobacterium Cf. Anabaena sp. " Bioorg. Med. Chem. 2012, 20, 6134-6143.

8. Kang, H. S.; Krunic, A.; Orjala, J. " Sanctolide A, a 14-Membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta. " Tetrahedron Lett. 2012, 53, 3563-3567.

7. Kang, H. S.; Krunic, A.; Orjala, J. " Stigonemapeptin, Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp. " J. Nat. Prod. 2012, 75, 807-811.

6. Kang, H. S.; Santarsiero, B. D.; Kim, H. J.; Krunic, A.; Shen, Q.; Swanson, S. M.; Chai, H. B.; Kinghorn, A. D.; Orjala, J. " Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial cyanobacterium Nostoc sp. " Phytochemistry 2012, 79, 109-115.

5. Kang, H. S.; Krunic, A.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides A-D, antiproliferative cyclic decapeptides from the cultured cyanobacterium Anabaena minutissima. " J. Nat. Prod. 2011, 74, 1597-1605.

Synthetic Microbiology LAB

26. Ji, C. H.; Kim, HY.; Kang, H. S. "Synthetic inducible regulatory systems optimized for the modulation of secondary metabolite production in Streptomyces." ACS Synth. Biol. 2019, 8(3), 577 - 586. (IF 5.316)

25. Ji, C. H.; Kim, J. P.; Kang, H. S. "Library of synthetic Streptomyces regulatory sequences for use in promoter engineering of natural product biosynthetic gene clusters." ACS Synth. Biol. 2018, 7(8), 1946-1955. (IF 5.316)

24. May D. S.; Kang, H. S.; Santarsiero B. D.; Krunic A.; Shen Q.; Burdette J. E.; Swanson S. M.; Orjala J. "Ribocyclophanes A-E, glycosylated cyclophanes with antiproliferative activity from two cultured terrestrial Cyanobacteria." J. Nat. Prod. 2018, 81, 572-8. (IF 3.885)

*Co-first author

23. Kang, H. S.; Ji, S. A.; Park, S. H.; Kim, J. P. "Lepistatins A-C, chlorinated sesquiterpenes from the cultured Basidiomycete Lepista sordida. " Phytochemistry 2017, 143, 111-4. (IF 3.205)

22. Kang, H. S. "Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products." J. Ind. Microbiol. Biotechnol. 2017, 44, 285-93. (IF 2.81)

- Featured in the cover

21. Kang, H. S.; Kim, J. P. "Ostalactones A - C, β- and ε-lactones with lipase inhibitory activity from the cultured Basidiomycete Stereum ostrea." J. Nat. Prod. 2016, 79, 3148-51. (IF 3.885)

20. Kang, H. S.; Charlop-Powers, Z.; Brady, S. F. "Multiplex CRISPR/Cas9- and TAR-mediated promoter engineering of natural products biosynthetic gene clusters." ACS Synth. Biol. 2016, 16, 1002-10. (IF 6.076)

18. Montiel, D.; Kang, H. S.; Chang, F. Y.; Charlop-Powers Z.; Brady, S. F. " Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. " Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 8953-8. (IF 9.661)

*Co-first author

16. Kang, H. S.; Brady, S. F. "Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study." J. Am. Chem. Soc. 2014, 136, 18111-18119. (IF 13.858)

15. Luo, S.; Krunic, A.; Kang, H. S.; Chen, W.-L.; Woodard, J.; Fuchs, J.; Swanson, S.; Orjala, J. "Trichormamides A and B with antiproliferative activity from the cultured freshwater Cyanobacterium Trichormus sp. " J. Nat. Prod. 2014, 77, 1871-1880. (IF 3.281)

14. Biggins, J. B.; Kang, H. S.; Ternei, M. A.; DeShazer, D.; Brady, S. F. "Secondary metabolism of Burkholderia pseudomallei is essential for pathogenicity." J. Am. Chem. Soc. 2014, 136, 9484-9490. (IF 13.858, JCR top 10%)

13. Kang, H. S.; Brady, S. F. "Arixanthomycins A-C: phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. " ACS Chem. Biol. 2014, 9, 1267-1272. (IF 4.995, JCR top 30%)

11. Kang, H. S.; Brady, S. F. "Arimetamycin A: improving clinically relevant families of natural products through sequence guided screening of soil metagenomes." Angew. Chem. Int. Ed. 2013, 52, 11063-11067. (IF 11.994)

- Selected as the cover paper

10. Kallifidas, D.; Kang, H. S.; Brady, S. F. "Tetarimycin A, an MRSA active antibiotic identified through induced expression of environmental DNA gene clusters." J. Am. Chem. Soc. 2012, 134, 19552-19555. (IF 13.858)

- Highlighted by C&E News and Nature medicine

9. Kang, H. S.; Sturdy, M.; Krunic, A.; Kim, H. J.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides E – L, antiproliferative cyclic lipodecapeptides from the cultured cyanobacterium Cf. Anabaena sp. " Bioorg. Med. Chem. 2012, 20, 6134-6143.

8. Kang, H. S.; Krunic, A.; Orjala, J. " Sanctolide A, a 14-Membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta. " Tetrahedron Lett. 2012, 53, 3563-3567.

7. Kang, H. S.; Krunic, A.; Orjala, J. " Stigonemapeptin, Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp. " J. Nat. Prod. 2012, 75, 807-811.

6. Kang, H. S.; Santarsiero, B. D.; Kim, H. J.; Krunic, A.; Shen, Q.; Swanson, S. M.; Chai, H. B.; Kinghorn, A. D.; Orjala, J. " Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial cyanobacterium Nostoc sp. " Phytochemistry 2012, 79, 109-115.

5. Kang, H. S.; Krunic, A.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides A-D, antiproliferative cyclic decapeptides from the cultured cyanobacterium Anabaena minutissima. " J. Nat. Prod. 2011, 74, 1597-1605.

2008 and before

​

26. Ji, C. H.; Kim, HY.; Kang, H. S. "Synthetic inducible regulatory systems optimized for the modulation of secondary metabolite production in Streptomyces." ACS Synth. Biol. 2019, 8(3), 577 - 586. (IF 5.316)

​

25. Ji, C. H.; Kim, J. P.; Kang, H. S. "Library of synthetic Streptomyces regulatory sequences for use in promoter engineering of natural product biosynthetic gene clusters." ACS Synth. Biol. 2018, 7(8), 1946-1955. (IF 5.316)

​

24. May D. S.*; Kang, H. S.*; Santarsiero B. D.; Krunic A.; Shen Q.; Burdette J. E.; Swanson S. M.; Orjala J. "Ribocyclophanes A-E, glycosylated cyclophanes with antiproliferative activity from two cultured terrestrial Cyanobacteria." J. Nat. Prod. 2018, 81, 572-8. (IF 3.885)

*Co-first author

​

23. Kang, H. S.; Ji, S. A.; Park, S. H.; Kim, J. P. "Lepistatins A-C, chlorinated sesquiterpenes from the cultured Basidiomycete Lepista sordida. " Phytochemistry 2017, 143, 111-4. (IF 3.205)

​

22. Kang, H. S. "Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products." J. Ind. Microbiol. Biotechnol. 2017, 44, 285-93. (IF 2.81)

- Featured in the cover

​

21. Kang, H. S.; Kim, J. P. "Ostalactones A - C, β- and ε-lactones with lipase inhibitory activity from the cultured Basidiomycete Stereum ostrea." J. Nat. Prod. 2016, 79, 3148-51. (IF 3.885)

​

20. Kang, H. S.; Charlop-Powers, Z.; Brady, S. F. "Multiplex CRISPR/Cas9- and TAR-mediated promoter engineering of natural products biosynthetic gene clusters." ACS Synth. Biol. 2016, 16, 1002-10. (IF 6.076)

​

​

18. Montiel, D.*; Kang, H. S.*; Chang, F. Y.; Charlop-Powers Z.; Brady, S. F. " Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. " Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 8953-8. (IF 9.661)

*Co-first author

​

16. Kang, H. S.; Brady, S. F. "Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study." J. Am. Chem. Soc. 2014, 136, 18111-18119. (IF 13.858)

​

15. Luo, S.; Krunic, A.; Kang, H. S.; Chen, W.-L.; Woodard, J.; Fuchs, J.; Swanson, S.; Orjala, J. "Trichormamides A and B with antiproliferative activity from the cultured freshwater Cyanobacterium Trichormus sp. " J. Nat. Prod. 2014, 77, 1871-1880. (IF 3.281)

​

14. Biggins, J. B.; Kang, H. S.; Ternei, M. A.; DeShazer, D.; Brady, S. F. "Secondary metabolism of Burkholderia pseudomallei is essential for pathogenicity." J. Am. Chem. Soc. 2014, 136, 9484-9490. (IF 13.858, JCR top 10%)

​

13. Kang, H. S.; Brady, S. F. "Arixanthomycins A-C: phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. " ACS Chem. Biol. 2014, 9, 1267-1272. (IF 4.995, JCR top 30%)

​

​

11. Kang, H. S.; Brady, S. F. "Arimetamycin A: improving clinically relevant families of natural products through sequence guided screening of soil metagenomes." Angew. Chem. Int. Ed. 2013, 52, 11063-11067. (IF 11.994)

- Selected as the cover paper

10. Kallifidas, D.; Kang, H. S.; Brady, S. F. "Tetarimycin A, an MRSA active antibiotic identified through induced expression of environmental DNA gene clusters." J. Am. Chem. Soc. 2012, 134, 19552-19555. (IF 13.858)

- Highlighted by C&E News and Nature medicine

​

9. Kang, H. S.; Sturdy, M.; Krunic, A.; Kim, H. J.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides E – L, antiproliferative cyclic lipodecapeptides from the cultured cyanobacterium Cf. Anabaena sp. " Bioorg. Med. Chem. 2012, 20, 6134-6143.

​

8. Kang, H. S.; Krunic, A.; Orjala, J. " Sanctolide A, a 14-Membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta. " Tetrahedron Lett. 2012, 53, 3563-3567.

7. Kang, H. S.; Krunic, A.; Orjala, J. " Stigonemapeptin, Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp. " J. Nat. Prod. 2012, 75, 807-811.

​

6. Kang, H. S.; Santarsiero, B. D.; Kim, H. J.; Krunic, A.; Shen, Q.; Swanson, S. M.; Chai, H. B.; Kinghorn, A. D.; Orjala, J. " Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial cyanobacterium Nostoc sp. " Phytochemistry 2012, 79, 109-115.

​

5. Kang, H. S.; Krunic, A.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides A-D, antiproliferative cyclic decapeptides from the cultured cyanobacterium Anabaena minutissima. " J. Nat. Prod. 2011, 74, 1597-1605.

​

2008 and before

​

24. May D. S.; Kang, H. S.; Santarsiero B. D.; Krunic A.; Shen Q.; Burdette J. E.; Swanson S. M.; Orjala J. "Ribocyclophanes A-E, glycosylated cyclophanes with antiproliferative activity from two cultured terrestrial Cyanobacteria." J. Nat. Prod. 2018, 81, 572-8. (IF 3.885)

18. Montiel, D.; Kang, H. S.; Chang, F. Y.; Charlop-Powers Z.; Brady, S. F. " Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. " Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 8953-8. (IF 9.661)