39. Kim, HY; Kang, H.S. "Metagenomics-based identification of 'Entotheonella' as the producer of sponge-derived metabolites halicylindramides" - Manuscript in Preparation
38. Ji, C. H.; Kang, H. S. "Natural and selective production of daptomycin in enigineered Streptomyces roseosporus" - Manuscript in Preparation
37. Kim, H; Kim, U; Ji, C. H.; Shin, H. Y.; Shim, S. H.; Kang, H. S. "Rapacrycins, new polyene natural products discovered through heterologous expression of a reducing type II PKS biosynthetic gene cluster with a new hybrid genotype." - Manuscript in Preparation
36. Ji, C. H.; Je, H. W.; Kim, H.; Kang, H. S. "Promoter engineering of natural product biosynthetic gene clusters in Actinomycetes: Concepts and Applications." Nat. Prod. Rep. 2024, In Press (IF 11.9)
35. Lee, S.; Park, I. G.; Choi, J. W.; Song, J. Y.; Lee, J. W.; Hur, J.-S.; Kim, Y.; Nam, S.-J.; Kang, H. S.; Deyrup, S. T.; Noh, M.; Shim, S. H. "Daldipyrenones A-C: Caged [6,6,6,6,6] polyketides derived from an endolichenic fungus Daldinia pyrenaica 047188" Org. Lett. 2023, 25(36), 6725-6729. (IF 5.2)
34. Kim, H.; Kim, J. Y.; Ji, C. H.; Lee, D.; Shim, S. H.; Joo, H. S.; Kang, H. S. "Acidonemycines A-C, new glycosylated anthracyclines with anti-virulence activity produced by the acidic culture of Streptomyces indonesiensis." J. Nat. Prod. 2023, 86, 8, 2039-2045 (IF 5.1)
33. Choi, J. W.; Lee, Y.; Kim, J.; Kwon, H.; Deyrup, S. T.; Lee, J. W.; Lee, D.; Kang, H. S.; Joo, H.; Shim, S. H. "Discovery of bioactive metabolites by acidic stress to a geldanamycin producer, Streptomyces samsunensis." J. Nat. Prod. 2023, 86, 947-957. (IF 5.1)
32. Je, H. W.; Ji, C. H.; Kim, H; Kang, H. S. "CaExTun: Mitigating Cas9-related toxicity in Streptomyces through species-specific expression tuning with randomized constitutive promoters." ACS Synth. Biol. 2023, 12, 61-70. (IF 5.249)
31. Ku, H; Lee, Y; Lee, S; Lee, J. W.; Kang, H. S.; Joo, H.-S.; Shim, S. H. "New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity" J. Antibiot. 2023, 76, 57-64. (IF 3.424)
30. Ji, C. H.; Kim, H. Y.; Je, H. W.; Lee, D. H.; Kang, H. S. "Top-down synthetic biology approach for titer improvement of clinically important antibiotic daptomycin in Streptomyces roseosporus NRRL11379." Metabolic Engineering 2022, 69(1), 40-49. (IF 9.783)
29. Chung, Y. H.; Kim, H.; Ji, C. H.; Je, H. W.; Lee, D.; Shim, S. H.; Joo, H. S.; Kang, H. S. "Comparative genomics reveals a remarkable biosynthetic potential of the Streptomyces phylogenetic lineage associated with rugose ornamented spores." mSystems 2021, 6(4), e00489-21 (IF 6.496)
28. Kang, H. S.; Kim, E. S. "Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts." Curr. Opin. Biotechnol. 2021, 69, 118-127. (IF 8.288)
27. Kim, HY.; Ji, C. H.; Je, H. W.; Kim, J. P.; Kang, H. S. "mpCRISTAR: Multiple plasmid approach for CRISPR/Cas9 and TAR-mediated multiplexed refactoring of natural product biosynthetic gene clusters." ACS Synth. Biol. 2020, 9(1), 175-180. (IF 5.571)
*Co-first author
- Featured in the cover
21. Kang, H. S.; Kim, J. P. "Ostalactones A - C, β- and ε-lactones with lipase inhibitory activity from the cultured Basidiomycete Stereum ostrea." J. Nat. Prod. 2016, 79, 3148-51. (IF 3.885)
20. Kang, H. S.; Charlop-Powers, Z.; Brady, S. F. "Multiplex CRISPR/Cas9- and TAR-mediated promoter engineering of natural products biosynthetic gene clusters." ACS Synth. Biol. 2016, 16, 1002-10. (IF 6.076)
19. Cohen, L. J.; Kang, H. S.; Chu, J.; Huang, Y. H.; Gordon, E. A.; Reddy, B. V.; Ternei, M. A.; Craig, J. W.; Brady, S. F. "Functional metagenomic discovery of bacterial effectors in the human microbiome led to the isolation of GPCR G2A/132 agonist commendamide." Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 4825-34. (IF 9.661)
18. Montiel, D.*; Kang, H. S.*; Chang, F. Y.; Charlop-Powers Z.; Brady, S. F. " Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. " Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 8953-8. (IF 9.661)
*Co-first author
17. Luos, S.; Kang, H. S.; Krunic, A.; Chen, W. L.; Yang, J.; Woodard, J. L.; Fuchs, J. R.; Cho, S. H.; Franzblau, S. G.; Swanson, S. M.; Orjala, J. "Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscilatoria sp. UIC 10045" Bioorg. Med. Chem. 2015, 23, 3153-62. (IF 2.93)
16. Kang, H. S.; Brady, S. F. "Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study." J. Am. Chem. Soc. 2014, 136, 18111-18119. (IF 13.858)
15. Luo, S.; Krunic, A.; Kang, H. S.; Chen, W.-L.; Woodard, J.; Fuchs, J.; Swanson, S.; Orjala, J. "Trichormamides A and B with antiproliferative activity from the cultured freshwater Cyanobacterium Trichormus sp. " J. Nat. Prod. 2014, 77, 1871-1880. (IF 3.281)
14. Biggins, J. B.; Kang, H. S.; Ternei, M. A.; DeShazer, D.; Brady, S. F. "Secondary metabolism of Burkholderia pseudomallei is essential for pathogenicity." J. Am. Chem. Soc. 2014, 136, 9484-9490. (IF 13.858, JCR top 10%)
13. Kang, H. S.; Brady, S. F. "Arixanthomycins A-C: phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. " ACS Chem. Biol. 2014, 9, 1267-1272. (IF 4.995, JCR top 30%)
12. Luo, S.; Kang, H. S.; Krunic, A.; Chlipala, G. E.; Cai, G.; Chen, W. L.; Franzblau, S. G.; Swanson, S. M.; Orjala, J. "Carbamidocyclophanes F and G with anti-Mycobacterium tuberculosis activity from the cultured freshwater cyanobacterium Nostoc sp." Tetrahedron Lett. 2014, 55, 686-689. (IF 2.193)
11. Kang, H. S.; Brady, S. F. "Arimetamycin A: improving clinically relevant families of natural products through sequence guided screening of soil metagenomes." Angew. Chem. Int. Ed. 2013, 52, 11063-11067. (IF 11.994)
- Selected as the cover paper
10. Kallifidas, D.; Kang, H. S.; Brady, S. F. "Tetarimycin A, an MRSA active antibiotic identified through induced expression of environmental DNA gene clusters." J. Am. Chem. Soc. 2012, 134, 19552-19555. (IF 13.858)
- Highlighted by C&E News and Nature medicine
9. Kang, H. S.; Sturdy, M.; Krunic, A.; Kim, H. J.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides E – L, antiproliferative cyclic lipodecapeptides from the cultured cyanobacterium Cf. Anabaena sp. " Bioorg. Med. Chem. 2012, 20, 6134-6143.
8. Kang, H. S.; Krunic, A.; Orjala, J. " Sanctolide A, a 14-Membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta. " Tetrahedron Lett. 2012, 53, 3563-3567.
7. Kang, H. S.; Krunic, A.; Orjala, J. " Stigonemapeptin, Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp. " J. Nat. Prod. 2012, 75, 807-811.
6. Kang, H. S.; Santarsiero, B. D.; Kim, H. J.; Krunic, A.; Shen, Q.; Swanson, S. M.; Chai, H. B.; Kinghorn, A. D.; Orjala, J. " Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial cyanobacterium Nostoc sp. " Phytochemistry 2012, 79, 109-115.
5. Kang, H. S.; Krunic, A.; Shen, Q.; Swanson, S. M.; Orjala, J. " Minutissamides A-D, antiproliferative cyclic decapeptides from the cultured cyanobacterium Anabaena minutissima. " J. Nat. Prod. 2011, 74, 1597-1605.
2008 and before
4. Kang, H. S.; Kim, K. R.; Jun, E. M.; Park, S. H.; Lee, T. S.; Suh, J. W.; Kim, J. P. Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus. Bioorg. Med. Chem. Lett. 2008, 18, 4047-4050.
3. Lee, Y. G.; Kang, H. S.; Kim, M. S.; Son, T. I. Thermally cross-linked anionic hydrogels composed of poly(vinyl alcohol) and poly (γ-glutamic acid): Preparation, characterization, and drug permeation behavior. J. Appl. Polym. Sci. 2008, 109, 3768-3775.
2. Kang, H. S.; Jun, E. M.; Park, S. H.; Heo, S. J.; Yoo, I. D.; Kim, J. P. Cyathusals A, B and C, New Antioxidants from the Fermented Mushroom Cyathus Sterocoreus. J. Nat. Prod. 2007, 70, 1043-1045.
1. Kang, H. S.; Park, S. H.; Lee, Y. G.; Son, T. I. Polyelectrolyte complex hydrogel composed of chitosan and poly(r-glutamic acid) for biological application: Preparation, physical properties, and cytocompatibility. J. Appl. Polym. Sci. 2006, 103, 386-394.